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專注于生物學(xué)試劑及試劑盒領(lǐng)域
服務(wù)熱線：18101056239
產(chǎn)品型號：K200048M
更新時間：2022-08-15
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Anti-HSP70 Monoclonal Antibody
| 英文名稱 | Anti-HSP70 Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 別名 | heat shock protein 70 |
| 應(yīng)用 | WB IF |
| 稀釋比例 | WB 1:1000-2000. IF 1:100-200. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 70kDa |
| Gene ID | 3303/3304 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P0DMV8/P0DMV9 |
| 克隆號 | 3G10 |
| 克隆類型 | Monoclonal Antibody |
| 背景資料 | The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress. Hsp70 is usually in an ATP bound state. Hsp70 by itself is characterized by a very weak ATPase activity, such that spontaneous hydrolysis will not occur for many minutes. As newly synthesized proteins emerge from the ribosomes, the substrate binding domain of Hsp70 recognizes sequences of hydrophobic amino acid residues, and interacts with them. This spontaneous interaction is reversible, and in the ATP bound state Hsp70 may relatively freely bind and release peptides. However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow rate of ATP hydrolysis. |
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