北京索萊寶科技有限公司
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專注于生物學試劑及試劑盒領域
服務熱線：18101056239
產(chǎn)品型號：K200027M
更新時間：2022-08-15
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Anti-Cleaved PARP Monoclonal Antibody
| 英文名稱 | Anti-Cleaved PARP Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 別名 | PARP-1; Poly(ADP ribose) polymerase 1; sPARP1;ADPRT1; ADP ribosyltransferase NAD(+) |
| 應用 | WB |
| 稀釋比例 | WB 1:1000-3000. |
| 交叉反應 | Human |
| 蛋白分子量 | 116kDa(Pro)89kDa(Active) |
| Gene ID | 142 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Nucleus |
| Swiss Prot | P09874 |
| 克隆號 | M4 |
| 克隆類型 | Monoclonal Antibody |
| 背景資料 | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
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