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產(chǎn)品中心抗體Monoclonal AntibodyK200026MAnti-PARP Monoclonal Antibody
產(chǎn)品型號：K200026M
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：1304
010-50973130
產(chǎn)品分類
Anti-PARP Monoclonal Antibody
| 英文名稱 | Anti-PARP Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 別名 | PARP-1; Poly(ADP ribose) polymerase 1; sPARP1;ADPRT1; ADP ribosyltransferase NAD(+) |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:1000-3000. IHC 1:200-500. |
| 交叉反應(yīng) | Human |
| 蛋白分子量 | 116kDa |
| Gene ID | 142 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Nucleus |
| Swiss Prot | P09874 |
| 克隆號 | M3 |
| 克隆類型 | Monoclonal Antibody |
| 背景資料 | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
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